Coronary Calcium Scoring and Modifiable Coronary Risk Factors

  • Lucky Sharma Kathmandu Medical College Teaching Hospital https://orcid.org/0000-0003-3178-8462
  • Dambar Bahadur Karki Kathmandu Medical College Teaching Hospital
  • Aanchal Shahi Kathmandu Medical College Teaching Hospital
  • Dikshya Sharma Kathmandu Medical College Teaching Hospital
Keywords: calcium, coronary angiography, coronary artery disease, ischemic heart disease, risk factors

Abstract

Introduction: Non-invasive coronary calcium scoring predicts earliest atherosclerotic changes in the coronary arteries on the basis of amount of calcium deposited in the coronary arteries. This study was done to analyze calcium scores in patients with different risk factors for coronary artery disease (CAD).

Methods: This was a cross sectional study conducted from 1st November 2015 to 30th April 2016 at Kathmandu Medical College Teaching Hospital. Patient with cardiovascular risk factors were included in the study. These patients underwent coronary calcium scoring. Calcium scores were then compared with the presence of risk factors.

Results: Total 467 participants were included in the study. There were 309 (62.2%) males and 158 (33.8%) females. Mean age of patient was 56.6 year (SD = 12.7). The difference in the scores observed with presence or absence of risk factors were statistically significant for gender, smoking, and hypertriglyceridemia (p<0.05) but not significant for impaired fasting glucose, hypertension, and body mass index.

Conclusion: This study suggested that presence of traditional risk factors does not necessarily indicate high coronary calcium level.

Downloads

Download data is not yet available.

Author Biographies

Lucky Sharma, Kathmandu Medical College Teaching Hospital

Lecturer, Department of Medicine

Dambar Bahadur Karki, Kathmandu Medical College Teaching Hospital

Professor, Department of Medicine

Aanchal Shahi, Kathmandu Medical College Teaching Hospital

Medical Officer, Department of Medicine

Dikshya Sharma, Kathmandu Medical College Teaching Hospital

Medical Officer, Department of Medicine

References

1. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet. 2006;367(9524):1747–57. DOI: 10.1016/S0140-6736(06)68770-9 PMID: 16731270
2. Sharma RK, Sharma RK, Voelker DJ, Singh VN, Pahuja D, Nash T, et al. Cardiac risk stratification: Role of the coronary calcium score. Vasc Health Risk Manag. 2010;6:603–11. DOI: 10.2147/VHRM.S8753 PMID: 20730016
3. Arad Y, Spadaro LA, Goodman K, Newstein D, Guerci AD. Prediction of coronary events with electron beam computed tomography. J Am Coll Cardiol. 2000 Oct;36(4):1253–60. DOI: 10.1016/S0735-1097(00)00872-X PMID: 11028480
4. Nadeem M, Ahmed SS, Mansoor S, Farooq S. Risk factors for coronary heart disease in patients below 45 years of age. Pak J Med Sci. 2013;29(1):91–96. DOI: 10.12669/pjms.291.2828
5. Mintz GS, Pichard AD, Popma JJ, Kent KM, Satler LF, Bucher TA, et al. Determinants and correlates of target lesion calcium in coronary artery disease: a clinical, angiographic and intravascular ultrasound study. J Am Coll Cardiol. 1997 Feb;29(2):268–74. DOI: 10.1016/S0735-1097(96)00479-2 PMID: 9014977
6. Faletra FF, Klersy C, D’Angeli I, Penco M, Procaccini V, Pasotti E, et al. Relation between coronary atherosclerotic plaques and traditional risk factors in people with no history of cardiovascular disease undergoing multi-detector computed coronary angiography. Heart. 2009;95(15):1265–1272. DOI: 10.1136/hrt.2009.167098 PMID: 19406736
7. Van Velzen JE, Schuijf JD, de Graaf FR, Nucifora G, Pundziute G, Jukema JW, et al. Plaque type and composition as evaluated non-invasively by MSCT angiography and invasively by VH IVUS in relation to the degree of stenosis. Heart. 2009;95(24):1990–1996. DOI: 10.1136/hrt.2009.176933 PMID: 19846418
8. World Health Organization. The global burden of disease: 2004 update. Geneva; World Health Organization: 2008. http://www.who.int/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf.
9. World Health Organization, World Bank. The Global burden of disease : a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020 : summary. In: Murray CJL, Lopez AD. eds. Boston: Harvard School of Public Health; 1996. http://www.who.int/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf
10. Vaidya A, Pokharel PK, Nagesh S, Karki P, Kumar S, Majhi S. Prevalence of coronary heart disease in the urban adult males of eastern Nepal. Population based analytic cross sectional study. Indian Heart J. 2009;61(4):431-437. PMID: 20635736
11. Nakamura M. Angiography is the gold standard and objective evidence of myocardial ischemia is mandatory if lesion severity is questionable. Circ J. 2011;75(1):204–210. DOI: 10.1253/circj.CJ-10-0881 PMID: 21173507
Lucky Sharma Photo
Published
2017-12-14
How to Cite
1.
Sharma L, Karki D, Shahi A, Sharma D. Coronary Calcium Scoring and Modifiable Coronary Risk Factors. J Lumbini Med Coll [Internet]. 14Dec.2017 [cited 22May2022];5(2):54 -57. Available from: https://jlmc.edu.np/index.php/JLMC/article/view/144
Section
Original Research Article