Hypovitaminosis D in Healthy Health Care Professionals: A Real Deficiency or Necessity of New Reference Value for Specific Population?
DOI:
https://doi.org/10.22502/jlmc.v6i1.173Keywords:
health care professionals, hypovitaminosis D, risk factors, vitamin D deficiencyAbstract
Introduction:
Vitamin D, a steroid vitamin, has attracted noticeable interest of clinicians and researchers for decades because of its diverse array of biological functions. Various studies have shown that the level of vitamin D is low in significant proportion of healthy individuals. However, indoor workers especially health care professionals are not focused, particularly in Nepal. We aimed to measure level of vitamin D in apparently healthy health care professionals.
Methods:
A descriptive cross-sectional study was carried out in apparently healthy health care professionals working at Kathmandu University Hospital in Dhulikhel, Nepal. Structured questionnaire including socioÂdemographics, dietary habits, and anthropometric measurements was filled in by the participants. Total serum 25-hydroxy vitamin D was measured by Chemiluminescence Immunoassay (CLIA) technique. Results were analyzed with t-test, Chi-square test, and Pearson correlation test.
Results:
Data from 64 female and 47 male were analyzed, mean 25-hydroxy vitamin D level was 8.81 ng/dl (SD = 4). Almost all (98.2%, n = 109) participants had vitamin D lower than normal where 72.7% (n = 92) were deficient, 24.5% (n = 17) were insufficient, and only 2.7% (n = 2) were having adequate level. Non-specific body pain was the only factor among all we studied that was significantly associated with vitamin D levels (p = 0.002).
Conclusion:
Hypovitaminosis of 25-hydroxy vitamin D was found to be very common (98.2%) in apparently healthy health care subjects of Dhulikhel Hospital. This may necessitate further research to redefine the biological reference value for our population.
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References
Mahmoud AA, Khalil A. Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis. Egyptian Journal of Chest Diseases and Tuberculosis. 2014;63(3):651-655. DOI: https://doi.org/10.1016/j.ejcdt.2014.02.015
Mehlawat U, Singh P, Pande S. Current status of Vitamin-D deficiency in India. Innovations in pharmaceuticals and Pharmacotherapy. 2014;2(2):328–335. Available from: http://www.innpharmacotherapy.com/Archive.aspx?IssueID=7
Beloyartseva M, Mithal A, Kaur P, Kalra S, Baruah MP, Mukhopadhyay S, et al. Widespread vitamin D deficiency among Indian health care professionals. Arch Osteoporos. 2012;7:187–192. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23225296 DOI: https://doi.org/10.1007/s11657-012-0096-x
Shakiba M, Rafiee P and Mohammadi A. High Prevalence of Vitamin D Deficiency in Medical Staff Draws Attention to a Retraining Program for Vitamin D. Austin Journal of Nutrition and Food Sciences. 2015;3(2):1063. Available from http://austinpublishinggroup.com/nutrition-food-sciences/fulltext/ajnfs-v3-id1063.php
Knutsen KV, Brekke M, Gjelstad S, Lagerløv P. Vitamin D status in patients with musculoskeletal pain, fatigue and headache: a cross-sectional descriptive study in a multi-ethnic general practice in Norway. Scand J Prim Health Care. 2010;28(3):166–171. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20642395 DOI: https://doi.org/10.3109/02813432.2010.505407
Spiro A, Buttriss JL. Vitamin D: An overview of Vitamin D status and intake in Europe: Nutr Bull 2014; 39(4): 322–350 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25635171 DOI: https://doi.org/10.1111/nbu.12108
Stroud ML, Stilgoe S, Stott VE, Alhabian O, Salman K. Vitamin D: a review. Aust Fam Physician 2008;37(12):1002-1005. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19142273
National Institutes of Health, office of Dietary Supplements. Vitamin D – Fact Sheet for Health Professional. Available from https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
Kasab M, Alkhatib AJ, AbuBaker A, Ali S, Bjorklund G. Vitamin D deficiency and its Associated Predictors among patients visting Primary Health Care Center. Research Journal of Biological Sciences. 2015;10(4):78-80. Available from http://medwelljournals.com/abstract/?doi=rjbsci.2015.78.80
Al-Elq AH. The status of Vitamin D in medical students in the preclerkship years of a Saudi medical school. J Family Community Med. 2012;19(2):100–104. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22870413 DOI: https://doi.org/10.4103/2230-8229.98293
Beloyartseva M, Mithal A, Kaur P, Kalra S, Baruah MP, Mukhopadhyay S, et al. Widespread vitamin D deficiency among Indian health care professionals. Arch Osteoporos. 2012;7:187– 192. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23225296 DOI: https://doi.org/10.1007/s11657-012-0096-x
Hattapornsawan Y, Pangsuwan S, Ongphiphadhanakul B, Udomsubpayakun U. Prevalence of vitamin D deficiency in nurses at the Royal Irrigation Hospital. J Med Assoc Thai. 2012;95(12):1569–1574. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23390789
Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144 Pt A:138–145. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24239505 DOI: https://doi.org/10.1016/j.jsbmb.2013.11.003
Vierucci F, Del Pistoia M, Fanos M, Gori M, Carlone G, Erba P, et al. Vitamin D status and predictors of hypovitaminosis D in Italian children and adolescents: a cross-sectional study. Eur J Pediatr. 2013;172(12):1607–1617. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23959324 DOI: https://doi.org/10.1007/s00431-013-2119-z
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of Vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7):1911-1930. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21646368 DOI: https://doi.org/10.1210/jc.2011-0385
Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D Insufficiency among Free-Living Healthy Young Adults. Am J Med 2002;112(8):659–662. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12034416 DOI: https://doi.org/10.1016/S0002-9343(02)01091-4
Junaid K, Rehman A, Jolliffe DA, Wood K, Martineau AR. High prevalence of Vitamin D deficiency among women of child-bearing age in Lahore Pakistan, associating with lack of sun exposure and illiteracy. BMC Womens Health. 2015;15:83. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26458880 DOI: https://doi.org/10.1186/s12905-015-0242-x

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