Placental Thickness and Its Correlation with Gestational Age: A Cross-sectional Ultrasonographic Study
Abstract
Introduction: Placenta grows in size with the advancement of gestational age (GA) and plays an important role for delivery of nutrients from mother to fetus. Ultrasonography (USG) is implicated for the estimation of GA by using fetal growth parameters like Femur Length (FL), Bi-parietal Diameter (BPD), Head Circumference (HC), and Abdominal Circumference (AC). This study intends to observe the correlation between Placental Thickness (PT) and GA. Methods: It was an observational, cross-sectional, and analytical study conducted over a period of six months from November 2017 to April 2018. Fetal growth parameters i.e. FL, BPD, HC, and AC were measured to estimate GA. PT was also measured at the same time. Results: There was a positive correlation between PT and GA (r = 0.89, n=249, p < 0.001). Pearson correlation coefficient between the two variables at second and third trimesters were 0.81 and 0.49 respectively. Fisher r-to-z transformation was used to analyze the difference between those two coefficients and was found to be statistically significant (z = 4.6, p < 0.001). This indicates that there was a significant overall relationship between PT and GA. As GA increases, PT also increases. Conclusion: Our study observed a positive correlation between the PT and GA in second and third trimesters. Thickness of placenta can thus be used as a reliable parameter for the estimation of GA during the second and third trimesters, and can be used as a supplementary USG parameter along with FL, BPD, HC and AC.
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Mathai BM, Singla SC, Nittala PP, Chakravarti RJ, Toppo JN. Placental thickness: its correlation with ultrasonographic gestational age in normal and intrauterine growth-retarded pregnancies in the late second and third trimester. The Journal of Obstetrics and Gynecology of India. 2013 Aug 1;63(4):230-3. PMID: 24431647 DOI: 10.1007%2Fs13224-012-0316-8 [Publisher Full Text]
Azpurua H, Funai EF, Coraluzzi LM, Doherty LF, Sasson IE, Kliman M, Kliman HJ. Determination of placental weight using two-dimensional sonography and volumetric mathematic modeling. American Journal of Perinatology. 2010 Feb 1;27(2):151-5. DOI: 10.1055/s-0029-1234034 [Publisher Full Text]
Jehan I, Zaidi S, Rizvi S, Mobeen N, McClure EM, Munoz B, Pasha O, Wright LL, Goldenberg RL. Dating gestational age by last menstrual period, symphysis-fundal height, and ultrasound in urban Pakistan. International Journal of Gynecology & Obstetrics. 2010 Sep 1;110(3):231-4. PMID: 20537328 DOI: 10.1016%2Fj.ijgo.2010.03.030 [Publisher Full Text]
Wolfson RN, Zador IE, Halvorsen P, Andrews B, Sokol RJ. Biparietal diameter in premature rupture of membranes: Errors in estimating gestational age. Journal of Clinical Ultrasound. 1983 Sep;11(7):371-4. PMID: 6415121 DOI: 10.1002/jcu.1870110705
Pant S, Dashottar S. A correlative study to evaluate the gestational age by sonological measurement of placental thickness in normal second and third trimester pregnancy. International Journal of Advances in Medicine. 2017 Nov 22;4(6):1638-44. DOI: DOI: 10.18203/2349-3933.ijam20175181 [Publisher Full Text]
Mital P, Hooja N, Mehndiratta K. Placental thickness: a sonographic parameter for estimating gestational age of the fetus. Indian journal of Radiology and Imaging. 2002 Nov 1;12(4):553-4. [Publisher Full Text]
Hanretty KP. Obstetrics Illustrated. 6th ed. Endiburgh: Churchill Livingstone; 2003. pp. 9–12.
Hadlock FP, Deter RL, Harrist RB, Park SK. Fetal biparietal diameter: rational choice of plane of section for sonographic measurement. American Journal of Roentgenology. 1982 May 1;138(5):871-4. PMID: 6979175 DOI: 10.2214/ajr.138.5.871
Chitty LS, Altman DG, Henderson A, Campbell S. Charts of fetal size: 2. Head measurements. BJOG: An International Journal of Obstetrics & Gynaecology. 1994 Jan 1;101(1):35-43. PMID: 8297866 DOI: 10.1111/j.1471-0528.1994.tb13007.x
Campbell S, Wilkin D. Ultrasonic measurement of fetal abdomen circumference in the estimation of fetal weight. BJOG: An International Journal of Obstetrics & Gynaecology. 1975 Sep;82(9):689-97. PMID: 1101942
Chitty LS, Altman DG, Henderson A, Campbell S. Charts of fetal size: 4. Femur length. BJOG: An International Journal of Obstetrics & Gynaecology. 1994 Feb 1;101(2):132-5. PMID: 8305387 DOI: 10.1111/j.1471-0528.1994.tb13078.x
Agwuna KK, Eze CU, Ukoha PO, Umeh UA. Relationship between sonographic placental thickness and gestational age in normal singleton fetuses in Enugu, Southeast Nigeria. Annals of medical and health sciences research. 2016;6(6):335-40. PMID: 28540100 DOI: 10.4103/amhsr.amhsr_457_15 [Publisher Full Text]
Kakumanu PK, Kondragunta C, GandraNR,Yepuri H. Evaluation of placental thickness as an ultrasonographic parameter for estimating gestational age of the fetus in 2nd and 3rd trimesters. International Journal of Contemporary Medicine Surgery and Radiology. 2018;3(1):128-32. [Publisher Full Text]
Adhikari R, Deka PK, Tayal A, Chettri PK. Ultrasonographic Evaluation of Placental Thickness in Normal Singleton Pregnancies for Estimation of Gestation Age. International Journal of Medical Imaging. 2015;3(6):143-7. [Publisher Full Text]
World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. World Health Organization; 2016. Available from: http://apps.who.int/iris/bitstream/handle/10665/250796/9789241549912-engpdf;jsessionid=DF8B7FEF544FD24F5A866DE6E82C0F5F?sequence=1
Saxena S, Rao.A , Nigam RK, Madan GS, Yadu N: Ultrasonographic Measurement Of Placental Thickness And Its Correlation With Gestational Age : A Cross-Sectional Study. International Journal of Current Medical and Applied Sciences. 2016;10(3):138-43
Hoddick WK, Mahony BS, Callen PW, Filly RA. Placental thickness. Journal of Ultrasound in Medicine. 1985 Sep;4(9):479-82. PMID: 3903201
Thurston M, Weerakkody Y. Placental thickness. Obstetrics Gynaecology Radiopaedia 2001;16:67-70
Benirschke K, Kaufmann P. Pathology of the Human Placenta.2nd ed. 2nd ed. New York: Spring-Verlag; 1990. pp. 234–42
Ohagwu CC, Abu PO, Ezeokeke UO, Ugwu AC. Relationship between placental thickness and growth parameters in normal Nigerian foetuses. African Journal of Biotechnology. 2009;8(2). [Publisher Full Text]
Karthikeyan T, Subramaniam RK, Johnson WM, Prabhu K. Placental thickness & its correlation to gestational age & foetal growth parameters-a cross sectional ultrasonographic study. Journal of Clinical and Diagnostic research. 2012 Dec;6(10):1732. PMID: 23373039 DOI: 10.7860%2FJCDR%2F2012%2F4867.2652 [Publisher Full Text]
Ahmed A, Alrashid Rahim HO, Elgyoum AA, Elzaki A. The correlation between placental thickness and fetal age among the pregnant in Sudan. Scholars Journal of Applied Medical Sciences. 2014;2:395-8. [Publisher Full Text]
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