“Solidarity Trial”: A Feeling of Trust Towards COVID-19 Treatments

Keywords: COVID-19, Solidarity trial

Abstract

Corona Virus Disease (COVID-19) drugs are not being developed at the pace in which the disease is spreading throughout the world. WHO and its partners have announced the worldwide clinical trial on 18th March 2020, known as “Solidarity Trial” for greater co-ordination of developments of drugs. “Solidarity Trialis an international clinical trial to help find an effective treatment for COVID-19”. The trial is randomized, open-label and adaptive. This trial will analyze four treatment options against standard of care, after recruiting patients from various countries, and then will approach to their relative effectiveness against the disease. The aim of this trial is to rapidly explore if any of the administered drugs will slow progression of disease or improve survival.

The rationale of conducting “Solidarity Trial” is to reduce time taken by the trials. Randomized clinical trials generally take years to conduct, while, “Solidarity Trial” will reduce the duration by 80%. By enrolling patients from around the world, this trial might be able to provide result more rapidly than multiple small trials. Moreover, those small multiple trials will not be able to gather solid evidence required to determine the relative effectiveness of given unproven drugs. 

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Author Biography

Naresh Karki, Lumbini Medical College Teaching Hospital

Assistant Professor,

Depertment of Pharmacology.

References

Mullard A. Flooded by the torrent: the COVID-19 drug pipeline. Lancet. 2020;395(10232):1245- 46. PMID: 32305088. DOI: https://doi.org/10.1016/S0140-6736(20)30894-1

World Health Organization. “Solidarity” clinical trial for COVID-19 treatments [Internet]. WHO: Geneva; 2020 March. [cited 2020 May 7]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments

Kupferschmidt K, Cohen J. WHO launches global megatrial of the four most promising coronavirus treatments [Internet].Science; 2020 Mar 22. [cited 2020 May 8]Available from:https://www.sciencemag.org/news/2020/03/who-launches-global-megatrial-four-most-promising-coronavirus-treatments

Wang BCY, Wen D, Liu W, Wang J, Fan G, Ruan L, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe COVID-19. N Engl J Med. 2020;382(19):1787-99.Available from: https://www.nejm.org/doi/full/10.1056/NEJMoa2001282

Published
2020-06-10
How to Cite
1.
Karki N. “Solidarity Trial”: A Feeling of Trust Towards COVID-19 Treatments. J Lumbini Med Coll [Internet]. 10Jun.2020 [cited 9Jul.2020];8(1):2 pages. Available from: https://jlmc.edu.np/index.php/JLMC/article/view/335
Section
Perspective