Histopathological Study of Endometrial Biopsy Specimens for Abnormal Uterine Bleeding

  • Archana Tiwari Lumbini Medical College
  • Narinder kaur Lumbini Medical College
  • Sushila Jain Lumbini Medical College
  • Ramji Rai Lumbini Medical College
  • Surendra Kumar Jain Lumbini Medical College
Keywords: biopsy, endometrium, histology, uterine hemorrhage, uterine neoplasia

Abstract

Introduction: Endometrial specimen for abnormal uterine bleeding (AUB) is the one of the commonest specimens received in histopathology laboratory. Histopathological characteristics of endometrial tissues, as assessed by light microscopy, remains the diagnostic standard for the management of AUB. The objective of study is to find out the histopathological pattern of endometrium in AUB in the light of clinical details.

Methods: This was a prospective observational study carried out in the department of Pathology, Lumbini Medical College Teaching Hospital for a period of two years from June 2014 to May 2016. Formalin fixed endometrial specimens were processed, paraffin embedded, sectioned at 3-4 µm, stained with hematoxylin and eosin, and studied under light microscopy along with their demographics. Data were collected, entered and analyzed using SPSS version 20.

Results: The study included 100 cases of endometrial biopsy specimens with clinical diagnosis of AUB. Menstrual disturbances was found in wide age range between 17-75 years with the mean age of 45 (SD=13.36) years. Menorrhagia was the commonest (n=60, 60%) clinical presentation. Most (n=85; 85 %) endometrium had non-neoplastic lesions. Among them, normal endometrial patterns were commonest (n=50, 50 %). Neoplastic lesions (n=15, 15%) were distributed in all menstruation status with majority in postmenopause (n=7, 7%) and included malignant cases (n=5, 5%) among others.

Conclusion: Post-menopausal bleeding was common presentation among women with malignant and premalignant disease which was present in 15% of the cases together. Timely evaluation of AUB  by histopathology can be life saving with early tissue diagnosis and management.

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Author Biographies

Archana Tiwari, Lumbini Medical College

Lecturer

Department of Pathology

Narinder kaur, Lumbini Medical College

Lecturer

Department of Obstetrics and Gynecology

Sushila Jain, Lumbini Medical College

Assistant Professor

Department of Obstetrics and Gynecology

Ramji Rai, Lumbini Medical College

Professor

Department of Pathology

Surendra Kumar Jain, Lumbini Medical College

Professor

Department of Pathology

Published
2016-12-30
How to Cite
1.
Tiwari A, kaur N, Jain S, Rai R, Jain S. Histopathological Study of Endometrial Biopsy Specimens for Abnormal Uterine Bleeding. J Lumbini Med Coll [Internet]. 30Dec.2016 [cited 25Sep.2020];4(2):72 -76. Available from: https://jlmc.edu.np/index.php/JLMC/article/view/94
Section
Original Research Article