Coping with COVID-19
Severe acute respiratory syndrome corona virus (SARS-CoV-2) virus made its first appearance in Wuhan, China in December 2019. It has since spread like a wild fire across the globe with over five million corona virus disease (COVID-19) confirmed cases and almost three hundred fifty thousand deaths at the time of writing this article. This could however be only the tip of the iceberg considering the contagious nature of the SARS-CoV-2 virus and the rate at which it is spreading across the globe. China did well to contain the virus with strict lockdown measures, sealing the affected areas, active case finding, tracing, tracking and treating the COVID-19 cases at an astonishing speed. In the absence of specific treatment available as yet, treatment consists of mainly symptomatic management with some experimental medications. Antivirals, specifically Remdesivir has been a strong candidate for the treatment of COVID-19. However, it has yet to receive universal acceptance for the treatment of COVID-19. Chloroquine and Hydroxychloroquine seem to be effective in limiting the replication of SARS-CoV-2 virus in vitro. COVID-19 is highly pandemic in countries where malaria is least prevalent and least pandemic in countries where malaria is highly prevalent. These findings suggest the hypothesis that anti-malarial drugs have efficacy in the treatment of COVID-19.
Hendaus MA. Remdsivir in the treatment of Corona Virus Disease (COVID-19): A simplified summary. J Biomol Struct Dyn. 2020; [Epub ahead of print] PMID: 32396771 DOI: https://doi.org/10.1080/07391102.2020.1767691
Al-Tawfiq JA, Al-Homoud AH, Memish ZA. Remdesivir as a possible therapeutic option for the COVID-19. Travel Med Infect Dis. 2020;34:101615. PMID: 32145386 PMCID: PMC7129391 DOI: https://doi.org/10.1016/j.tmaid.2020.101615
Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S. A systematic review on efficacy and safety of chloroquine for treatment of COVID-19. J Crit Care. 2020;57: 279-283. PMID: 32173110 DOI: https://doi.org/10.1016/j.jcrc.2020.03.005
Meo SA, Klonoff DC, Akram J. Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19. Eur Rev Med Pharmacol Sci. 2020;28(8):4539-4547. DOI: https://doi.org/10.26355/eurrev_202004_21038
Ferner RE, Aronson JK. Chloroquine and hydroxychloroquine in COVID-19. BMJ. 2020;369:m1432. DOI: https://doi.org/10.1136/bmj.m1432
Shitto MO, Afolami OI. Improving efficacy of chloroquine and hydroxychloroquine against SARS-CoV-2 may require Zinc additives-A better synergy for future COVID-19 clinical trails. Infez Med. 2020;28(2):192-197. PMID: 32335560
Schmith VD, Zhou JJ, Lohmer LR. The approved dose of Ivermectin alone is not the ideal dose for the treatment of COVID-19. Clin Pharmacol Ther. 2020; [Epub ahead of print]. DOI: https://doi.org/10.1002/cpt.1889
McCartney DM, Byrne DG. Optimization of Vitamin D status for enhanced immune-protection against COVID-19. Ir Med J. 2020;113(4):58. PMID: 32268051
Grant WB, Lahore H, McDonnell SL, Baggerly CA, Fench CB, Aliano JL, et al. Evidence that Vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020;12(4):E988. DOI: https://doi.org/10.3390/nu12040988
Saghazadeh A, Rezaei N. Towards treatment planning of COVID-19: Rationale and hypothesis for the use of multiple immunosuppressive agents: Antibodies, Immunoglobulin and Cortcosteroids. Int Immunopharmacol. 2020;84:106560. DOI: https://doi.org/10.1016/j.intimp.2020.106560
Yang L, Tian D, Liu W. Strategies for vaccine development of COVID-19. Sheng Wu Gong Cheng Xue Bao. 2020;36(4):593-604. PMID: 32347054 DOI: https://doi.org/10.13345/j.cjb.200094
Kwok KD, Lai F, Wei WI, Wang SYS, Tang JWT. Herd immunity-Estimating the level required to halt COVID-19 epidemics in affected countries, J Infect. 2020;80(6):e32-e33. PMID: 32209383 PMCID: PMC7151357 DOI: https://doi.org/10.1016/j.jinf.2020.03.027
World Health Organization. Surveillance strategies for COVID-19 human infection: interim guidance, 10 May 2020. World Health Organization, 2020. Available from: https://apps.who.int/iris/handle/10665/332051
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