Background: Pemphigus is a worldwide disease and varies in its clinical profile and epidemiology in different regions of the world. The disease is rare and few epidemiological data are available. Objective: The purpose of this study was to evaluate the epidemiologic, clinical, and therapeutic features of pemphigus in Lumbini Medical College. Methods: We retrospectively investigated a total of 70 patients with pemphigus. The parameters including age at diagnosis, sex, diagnostic methods and treatment outcome of the disease. Results: The mean age at the onset was 41.3 years. The male-to-female ratio was 1.18:1. Most of the patients were cured at the end of the treatment. Rest were clinically improved. Conclusion: Pemphigus vulgaris (PV) is the most common clinical subtype in our centre. The disease is more frequent in the fifth decade of life and has a male predominance in our region.