COVID-19 Pandemic: A Neurological Perspective

Keywords: Angiotensin, COVID-19, Pandemic

Abstract

Even though severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system, the nervous system is not spared either. SARS-CoV-2 has been isolated from the brain, olfactory bulb and cerebrospinal fluid. During the SARS (SARS-CoV-1) outbreak in 2002 to 2003, neurons had been found to be highly susceptible for infection and the virus could cause extensive neuronal damage. Similar to SARS-CoV-1,
SARS-CoV-2 exploits the angiotensin-converting enzyme 2 (ACE-2) receptor to gain entry and infect both glial and neuronal cells which express ACE-2 receptors.[1] SARS-CoV-2 affects the central as well as peripheral nervous system presenting with diverse manifestations like myelitis, cerebrovascular events (CVE) and encephalitis to mention a few.[2,3] Indepth understanding of neurotropic potential of this virus will be helpful to individualize the treatment protocol from a neurological perspective.

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Author Biography

Suresh Bishokarma, Upendra Devkota Memorial National Institute of Neurological and Allied Sciences

MCh,

Department of Neurosurgery.

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Published
2020-05-26
How to Cite
1.
Bishokarma S. COVID-19 Pandemic: A Neurological Perspective. J Lumbini Med Coll [Internet]. 26May2020 [cited 9Jul.2020];8(1):3 pages. Available from: https://jlmc.edu.np/index.php/JLMC/article/view/334
Section
Perspective