Comparative Study on Effects of 2% Lidocaine Hydrochloride with Adrenaline (1:200000) on Blood Pressure Among Controlled Hypertensive and Non-hypertensive Patients During Dental Anesthesia

  • Lujaw Ratna Tuladhar Nepal Medical College Teaching Hospital, Kathmandu, Nepal. https://orcid.org/0000-0002-1626-1104
  • Meen Bahadur Budhathoki Nepal Medical College Teaching Hospital, Kathmandu, Nepal.
  • Anjali Bhattarai Nepal Medical College Teaching Hospital, Kathmandu, Nepal.
  • Kushal Bimb Nepal Medical College Teaching Hospital, Kathmandu, Nepal.
  • Nikhil Acharya Nepal Medical College Teaching Hospital, Kathmandu, Nepal.
  • Eans Tara Tuladhar Maharajgunj Medical Campus, Institute of Medicine, Kathmandu.
Keywords: Adrenaline, Adverse drug reaction, Anesthesia dental, Hypertension, Lidocaine

Abstract

Introduction: Local anesthetic used for dental extraction is 2% lidocaine hydrochloride with adrenaline (1:200000). Lidocaine is cardiac depressant and adrenaline is cardiac stimulant; it decreases or increases blood pressure respectively. Methods: A total of 100 patients (50 controlled hypertensive and 50 non-hypertensive) were selected. The study was conducted over a period of 14 months from January 2020 to February 2021. Blood pressure was measured for patients who were planned for dental extraction by auscultatory method. Following that, 1.5-3 ml (depending upon the nerve block) 2% lidocaine with adrenaline (1:200000) was injected using a 3ml syringe (26 Gauge). Blood pressure was re-recorded after 10 minutes from the time of injection. Visual analog scale pain score was obtained during administration of local anesthesia. Paired t-test was applied to compare blood pressure change before and after administration of local anesthesia in controlled hypertensive and non-hypertensive patients. Results: There was a statistically significant increase in both systolic and diastolic blood pressure in non-hypertensive patients (p = 0.008, p = 0.017). This, however, was not the case with controlled hypertensive patients. There was statistically significant increase in systolic blood pressure (p < 0.001). Pain on injection (50% in non-hypertensive and 48% in controlled hypertensive patients) was the only adverse drug reaction that was reported in both groups. Conclusion: 2% lidocaine hydrochloride with adrenaline (1:200000) increased systolic but not diastolic blood pressure in controlled hypertensive patients

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Author Biographies

Lujaw Ratna Tuladhar, Nepal Medical College Teaching Hospital, Kathmandu, Nepal.

Assistant Professor,

Department of Pharmacology.

Meen Bahadur Budhathoki, Nepal Medical College Teaching Hospital, Kathmandu, Nepal.

Lecturer,

Department of Oral and Maxillo-facial Surgery.

Anjali Bhattarai, Nepal Medical College Teaching Hospital, Kathmandu, Nepal.

Lecturer,

Department of Oral and Maxillo-facial Surgery.

Kushal Bimb, Nepal Medical College Teaching Hospital, Kathmandu, Nepal.

Lecturer,

Department of Oral and Maxillo-facial Surgery.

Nikhil Acharya, Nepal Medical College Teaching Hospital, Kathmandu, Nepal.

Lecturer,

Department of General Surgery.

Eans Tara Tuladhar, Maharajgunj Medical Campus, Institute of Medicine, Kathmandu.

Lecturer,

Department of Biochemistry.

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Published
2021-05-02
How to Cite
1.
Tuladhar L, Budhathoki M, Bhattarai A, Bimb K, Acharya N, Tuladhar ET. Comparative Study on Effects of 2% Lidocaine Hydrochloride with Adrenaline (1:200000) on Blood Pressure Among Controlled Hypertensive and Non-hypertensive Patients During Dental Anesthesia. J Lumbini Med Coll [Internet]. 2May2021 [cited 28Jul.2021];9(1):6 pages. Available from: https://jlmc.edu.np/index.php/JLMC/article/view/415
Section
Original Research Article