Morphological Variation of Circle of Willis in Nepali Population: A 3D Time-of-Flight Magnetic Resonance Angiography Based Study

  • Rupesh Sharma Lumbini Medical College and Teaching Hospital, Pravas, Palpa
  • Sona Pokharel Lumbini Medical College and Teaching Hospital
  • Phanendra Neupane Lumbini Medical College and Teaching Hospital
  • Rituraj Subedi Lumbini Medical College and Teaching Hospital
Keywords: Circle of Willis, Magnetic Resonance Angiography, Time of flight


Introduction: The Circle of Willis (COW) is an anatomic ring of vessels located at the base of brain connecting the anterior and posterior circulation by uniting the internal carotid and vertebrobasilar systems to maintain an adequate cerebral perfusion. The importance of a detailed information of the COW morphology and integrity in any patient cannot be overemphasized, especially for neuro-physicians, neurosurgeons and interventional neuroradiologists who are considering intervention to the intracranial arteries. This study was conducted to study the variation of COW among Nepalese population and compare the results with those of other nationalities. Methods: It was a prospective cross-sectional study performed using a 1.5 Tesla MRI machine. Results: A total of 118 patients were studied during the period out of which 75 (63.6%) were males and 43 (36.4%) were females. A morphologically normal COW configuration was found only in 55 (46.6%) cases whereas a variant configuration was present in 63 (53.4%) cases. The most common variation was noted in the PCOM which was present in 42 (67%) cases. The most common single variation in abnormal COW configuration was absent right PCOM. Conclusion: The morphologic variation of the COW is more common than the normal textbook configuration in Nepalese population, PCOM being the most commonly involved vessel.


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Author Biographies

Rupesh Sharma, Lumbini Medical College and Teaching Hospital, Pravas, Palpa

Assistant Professor,

Department of Radiology.

Sona Pokharel, Lumbini Medical College and Teaching Hospital


Department of Radiology.

Phanendra Neupane, Lumbini Medical College and Teaching Hospital


Department of Radiology.

Rituraj Subedi, Lumbini Medical College and Teaching Hospital


Department of Radiology.


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How to Cite
Sharma R, Pokharel S, Neupane P, Subedi R. Morphological Variation of Circle of Willis in Nepali Population: A 3D Time-of-Flight Magnetic Resonance Angiography Based Study. J Lumbini Med Coll [Internet]. 30Jun.2021 [cited 28Jul.2021];9(1):5 pages. Available from:
Original Research Article