Study of Association Between Glycated Hemoglobin and Lipid Profile in Type 2 Diabetes Mellitus in Tertiary Care Center

Keywords: Diabetes Mellitus, Glycated Hemoglobin, Lipid Profile


Introduction: Diabetes is one of the major burdens of non-communicable disease causing morbidity and mortality. Glycated hemoglobin (HbA1c) has been used as a tool to monitor glycemic control in patients with type 2 diabetes mellitus and elevated HbA1c value is considered an independent risk factor for dyslipidemia. Methods: A total of 120 patients with type 2 diabetes mellitus were enrolled in this cross-sectional study. Means with standard deviation were used for age, height, weight and fasting blood sugar and Pearson correlation test was applied to identify correlation between Glycated hemoglobin (HbA1c) and lipid profile. Comparison of means was done by Student 't' test in parametric data within the two groups. P value less than 0.05 was considered significant. Results: The mean HbA1c of male and female patients were 8.35±1.77 and 8.65±1.95 respectively. Among patients with good glycemic control, mean total cholesterol and mean high density lipoprotein were higher than poor glycemic control patients. Patients with poor glycemic control had higher mean triglyceride and low density lipoprotein than good glycemic control patients. Correlation coefficient for various components of lipid profile and HbA1c were: total cholesterol (r=0.189, p=0.038, n=120), triglyceride (r=0.418, p<0.01, n=120), low density lipoprotein (r=0.673,p<0.01,n=120) and high density lipoprotein ( r=-0.683, p<0.01, n=120). Conclusion: There was a significant moderate correlation between HbA1c and lipid profile. Lipid profile values were significantly higher in poor glycemic control than good glycemic control patients. Hence, HbA1c can be considered as a surrogate marker for dyslipidemia in type 2 DM patients.


Download data is not yet available.

Author Biographies

Tilchan Pandey, Lumbini Medical College and Teaching Hospital


Department of Internal Medicine.

Jivan Khanal, Lumbini Medical College and Teaching Hospital

Associate Professor,

Department of Internal Medicine.

Krishna Chandra Godar, Crimson Hospital, Manigram, Rupandehi, Nepal

Consultant Physician.


Rahimi HR, Mohammadpour AH, Dastani M, Jaafari MR, Abnous K, Mobarhan MG, et al. The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial. Avicenna journal of phytomedicine. 2016;6(5):567. DOI: PMID: 27761427.

Bhowmik B, Siddiquee T, Mujumder A, Afsana F, Ahmed T, Mdala IA, et al. Serum lipid profile and its association with diabetes and prediabetes in a rural Bangladeshi population. Int J Environ Res Public Health. 2018;15(9):1944. DOI:

American Diabetes Association. Standards of medical care in diabetes--2014. Diabetes Care. 2014;37 Suppl 1:S14-80. DOI: PMID: 24357209.

Hussain A, Ali I, Ijaz M, Rahim A. Correlation between hemoglobin A1C and serum lipid profile in Afghani patients with type 2diabetes: hemoglobin A1C prognosticates dyslipidemia. Therapeutic advances in endocrinology and metabolism. 2017;8(4):51-7. DOI: PMID: 28507727.

Baranwal JK, Maskey R, Majhi S, Lamsal M, Baral N. Association between level of HbA1c and lipid profile in T2DM patients attending diabetic OPD at BPKIHS. Health Renaissance. 2015;13(3):16-23. DOI:

Sapkota LB, Thapa S. Correlation between glycemic parameters and lipid profile in type 2 diabetic patients attending tertiary care centre in central region of Nepal. J Chitwan Med Coll. 2017;7(1):20-4. DOI:

Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486–2497.

DOI: doi:10.1001/jama.285.19.2486 PMID: 11368702.

Yadav NK, Sathian B, Kalai RS. Assessment of Diabetes Mellitus in India and Nepal. WebmedCentral BIOCHEMISTRY 2012; 3(6):WMC003544. DOI: doi:10.9754/journal.wmc.2012.003544

Lam DW, LeRoith D. The worldwide diabetes epidemic. Current Opinion in Endocrinology, Diabetes and Obesity. 2012; 19(2):93-6. DOI:

Hu FB. Globalization of diabetes the role of diet, lifestyle, and genes. Diabetes Care. 2011; 34(6):1249–1257. DOI: PMID: 21617109.

Rosiek A, Kornatowski T, Frąckowiak- Maciejewska N, Rosiek-Kryszewska A, Wyżgowski P, Leksowski K. Health behaviors of patients diagnosed with type 2 diabetes mellitus and their influence on the patients’ satisfaction with life. Therapeutics and Clinical Risk Management. 2016;12:1783. DOI:

Alzahrani SH, Baig M, Aashi MM, Al-Shaibi FK, Alqarni DA, Bakhamees WH. Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study. Diabetes Metab Syndr Obes. 2019;12:1639-1644. DOI: PMID: 31695459; PMCID: PMC6718241.

Naeem M, Khattak RM, Rehman M, Khattak MN. The role of glycated hemoglobin (HbA1c) and serum lipid profile measurements to detect cardiovascular diseases in type 2 diabetic patients. South East Asia Journal of Public Health. 2015; 5(2):30-4. DOI:

Kautzky-Willer A, Harreiter J, Pacini G. Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus. Endocrine reviews. 2016; 37(3):278-316.DOI:

Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, et al. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40-50. DOI: PMID: 28437734.

Gale EA, Gillespie KM. Diabetes and gender. Diabetologia. 2001;44(1):3-15. DOI: PMID: 11206408.

Wu NQ, Li JJ. Clinical considerations of lipid target and goal in dyslipidemia control. Chronic Diseases and Translational Medicine. 2016;2(1):3. DOI:

Hou Q, Yu C, Li S, Li Y, Zhang R, Zheng T, et al. Characteristics of lipid profiles and lipid control in patients with diabetes in a tertiary hospital in Southwest China: an observational study based on electronic medical records. Lipids in health and disease. 2019;18(1):13. DOI:

Guy J, Ogden L, Wadwa RP, Hamman RF, Mayer-Davis EJ, Liese AD, D'Agostino R Jr, Marcovina S, Dabelea D. Lipid and lipoprotein profiles in youth with and without type 1 diabetes: the SEARCH for Diabetes in Youth case-control study. Diabetes Care. 2009;32(3):416-20. DOI: PMID: 19092167; PMCID: PMC2646019.

How to Cite
Pandey T, Khanal J, Godar K. Study of Association Between Glycated Hemoglobin and Lipid Profile in Type 2 Diabetes Mellitus in Tertiary Care Center. J Lumbini Med Coll [Internet]. 2Dec.2020 [cited 11May2021];8(2):238-43. Available from:
Original Research Article